Nucleic Acids Research, 1989, Vol. 17, No. 9 3335-3346
© 1989
MOLECULAR BIOLOGY |
Involvement of a cis-element that binds an H2TF-l/NFxB like factor(s) in the virus-induced interferon-ß gene expression
Institute for Molecular and Cellular Biology, Osaka University Yamadaoka 1-3, Suita-shi, Osaka 565, Japan
Received March 13, 1989. Revised April 12, 1989. Accepted April 12, 1989.
Interferon-ß (IFN-ß) gene is transcriptionally activated following virus infection of various cell types such as fibroblasts. In the previous studies, regulatory DNA sequences that mediate the virus-induced transcriptional activation have been identified within the 5'-flanking region (up to around –117 respect to the CAP site) of the human IFN-ß gene. The sequences contain binding sites (–100 to –61) for a transcriptional activator, IRF-1, the gene of which is also virus-inducible. In the present study, we focused on an additional cis-element, located between the IRF-1 binding sites and TATA box. Interestingly, the element coincides with the previously identified elements for the transcription factors H2TF-1 and NFxB. The element, when tandemly repeated, functions in activating the distal gene expression in either constitutive or virus-inducible manner depending on the cell type. The results suggest the importance of cooperation between IRF-1 and H2TF-1/ NFxB-like factor in the maximal IFN-ß gene induction.
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