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Nucleic Acids Research, 1989, Vol. 17, No. 9 3387-3401
© 1989

MOLECULAR BIOLOGY

Sequence and organization of the mouse poly (ADP-ribose) polymerase gene

Konrad Huppi, Kishor Bhatia1, David Siwarski, Denis Klinman2, Barry Cherney1 and Mark Smulson1

Laboratory of Genetics NC1/NIH, Bldg 37, Rm 2B-21 Bethesda, MD 20892 1Department of Biochemistry, Georgetown University School of Mediciine Washington, DC 20007 2Laboratory of Molecular and Viral Pathogenesis NINDS/NIH Bethesda, MD, USA

Received February 17, 1989. Revised March 29, 1989. Accepted March 29, 1989.

Using a human cDNA probe, we have isolated murine genomic and cDNA clones corresponding to the nuclear enzyme poly (ADP-ribose) polymerase (ADPRP). Northern analysis with the mouse cDNA clones reveals transcripts of 3.7–3.8kb corresponding in size to the human ADPRP transcript. DNA sequence comparisons between mouse and human clones reveals extensive amino acid sequence conservation within regions harboring DNA binding, NAD+ binding or automodification domains. A survey among mouse inbred strains for restriction fragment length polymorphism (RFLP) reveals at least three distinct ADPRP alleles. The segregation of alleles among mouse genetic recombinants positions ADPRP on mouse chromosome 1 between the complement receptor-related gene At-3 and the Fc receptor locus FcR. Furthermore, ADPRP is closely associated with the autoimmune locus gld (generalized lymphadenopathy).


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