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Nucleic Acids Research, 1990, Vol. 18, No. 10 2855-2859
© 1990

CHEMISTRY

Abasic oligodeoxyribonucleoside phosphorothioates: synthesis and evaluation as anti-HIV-1 agents

Radhakrishnan P. Iyer, Bogdan Uznanski, Jila Boal, Christy Storm, William Egan*, Makoto Matsukura1, Samuel Broder1, Gerald Zon2, Andrzej Wilk3, Maria Koziolkiewicz3 and Wojciech J. Stec*,3

1Biophysics Laboratory, Center for Biologics Evaluation and Research, Food and Drug Administration and Clinical Oncology Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health Bethesda, MD 20892, Poland 2Applied Biosystems, Inc., 777 Lincoln Centre Drive Foster City, CA 94404, Poland 3Polish Academy of Sciences, Centre of Molecular and Macromolecular Studies, Department of Bio-organic Chemistry 90-362 Lodz, Boczna 5, Poland

*To whom correspondence should be addressed

Received March 14, 1990. Accepted April 18, 1990.

The syntheses and anti-HIV-1 evaluations of two abasic oligodeoxyribonucleotide phosphorothioate analogs, d[Cps(Epg)2gC] and d[Cps(Vps)26C] (where E and V derive from 1,2-dideoxy-D-ribofuranose and (±)-butane 1, 3-diol, respectively), are described.


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