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Nucleic Acids Research, 1990, Vol. 18, No. 10 2947-2951
© 1990

MOLECULAR BIOLOGY

The retrotransposon Copia controls the relative levels of its gene products post-transcriptionally be differential expression from its two major mRNAs

Cathy Brierley and Andrew J. Flavell*

Department of Biochemistry, The University of Dundee Dundee DD1 4HN, Uk

*Tp whom correspondence should be addressed

Received January 9, 1990. Accepted April 11, 1990.

All retroviruses and retrotransposons studied to date regulate the relative levels of gag and pol/lnt gene products post-transcriptionally from a single mRNA. In these geneti elements the production of protein encoded by the pol and int genes is attenuated by a translational stop or frameshift in the reading frame preceding their coding regions in the mRNA. We show here that the Drosophila retrotransposon copia also produces lower amounts of gene products from its int/pol region than gag region but this is achieved by a mechanism which is novel for this class of genetic element. We show by the use of gene fusion constructs that the subgenomic 2 kilobase copia RNA, encoding gag products, is expressed as protein in cultured cells at least ten-fold more efficiently than the full genome length RNA, which additionally contains the pol and Int open reading frames.


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