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Nucleic Acids Research, 1990, Vol. 18, No. 11 3155-3159
© 1990

CHEMISTRY

HELP (High Efficiency Liquid Phase) new oligonucleotide synthesis on soluble polymeric support

Gian Maria Bonora*, Carlo Luigi Scremin, Francesco Paolo Colonna1 and Anna Garbesi1

Department of Organic Chemistry, Biopolymer Research Center, CNR, Univerisity of Padova 35131 Padova 1ICo. CEA, CNR, 40064 Ozzano Emilia (BO) Italy

*Tp whom correspondence should be addressed

Received March 22, 1990. Accepted May 9, 1990.

A simple, rapid and high-yielding method for the synthesis of oligonucleotides by the phosphotriesters approach Is described. The use of polyethylene glycol (PEG) as soluble polymeric support preserves some convenient features of the solid-phase synthesis with new interesting advantages.Short oligonucleotides in hundred milligrams scale can be obtained from few grams of functionalised PEG.


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