Nucleic Acids Research, 1990, Vol. 18, No. 13 3841-3845
© 1990
MOLECULAR BIOLOGY |
MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III
Molecular Biology Institute and Department of Biology 405 Hilgard Ave University of California Los Angeles, CA 90024, USA
*To whom correspondence should be addressed
Received March 29, 1990. Revised June 1, 1990. Accepted June 1, 1990.
The mutY gene of Escherichia coli, which codes for an adenine glycosylase that excises the adenine of a G-A mispair, has been cloned and sequenced. The mutY gene codes for a protein of 350 amino acids (Mr = 39, 123) and the clone genetically complements the mutY strain. The protein shows significant sequence homology to E. coli endonuclease III, an enzyme that has previously been shown to have glycosylase activity on damaged base pairs. Sequence analysis suggests that, like endonuclease III, MutY is an iron-sulfur protein with a [4Fe-4S]2+ cluster.
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