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Nucleic Acids Research, 1990, Vol. 18, No. 13 3881-3885
© 1990

MOLECULAR BIOLOGY

A non-curved chicken lysozyme 5' matrix attachment site is 3' followed by a strongly curved DNA sequence

Jens P.von Kries, Loc Phi-Van+, Stephen Diekmann§ and Wolf H. Strätling*

Institute für Physiologische Chemie, Universitäts-Krankenhaus Eppendorf Martinistrasse 52, D-2000 Hamburg 20, FRG

*To whom correspondence should be addressed

Received March 21, 1990. Revised May 30, 1990. Accepted May 30, 1990.

Matrix attachment regions (MARs) partition the genome into functional and structural loop-domains. Here, we determined the relative matrix affinity of cloned fragments of the chicken lysozyme 5' MAR. We show that this region contains a non-curved high-affinity binding site, which is 3' followed by a strongly curved DNA sequence that exhibits weak matrix binding. DNA curvature is not a physical property required for strong matrix binding. Possible. biological functions of this sequence arrangement, particularly of the strongly curved DNA, are discussed.

+Present addresses: Institut fur Genetik und Toxikologie, Kernforschungszentrum Karlsruhe, Institut fur Genetik, Universitat Karlsruhe, D-7500 Karlsruhe

§Max-Planck-Institut fur Biophysikalische Chemie, Am FaBberg, D-3400 Gottingen, FRG


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