Skip Navigation

This Article
Right arrow Print PDF (1527K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (36)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Cianetti, L.
Right arrow Articles by Peschle, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cianetti, L.
Right arrow Articles by Peschle, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1990, Vol. 18, No. 15 4361-4368
© 1990

MOLECULAR BIOLOGY

Molecular mechanisms underlying the expression of the human HOX-5.1 gene

Luciano Cianetti*, Anna Di Cristofaro, Vincenzo Zappavigna, Lisa Bottero, Giovanni Boccoli, Ugo Testa, Giovanni Russo1, Edoardo Boncinelli2 and Cesare Peschle

Department of Hematology and Oncology, Istituto Superiore di Sanita Viale Regina Elena 299, 00161 Rome 1Clinica Ostetrica e Ginecologica, Ospedale Civile di Avellino 83100 Avellino 2International Institute of Genetics and Biophysics-CNR Via G. Marconi 10, 80125 Naples, Italy

*To whom correspondence should be addressed

Received May 30, 1990. Accepted June 13, 1990.

The complex mechanisms underlying homeobox genes expression involve regulation at transcriptional, posttranscriptional and translational levels. The multiple transcripts of the human HOX-5.1 gene are expressed differentially in tissue- and stage-specific patterns during embryogenesis, and differentially induced by retinoic acid (RA) in human embryonal carcinoma (EC) NT2/D1 cells. We have sequenced 6.3 Kb of the genomic region containing the HOX-5.1 gene and analyzed its mechanisms of expression. Two alternative promoters underlie the transcription of two classes of HOX-5.1-specific mRNAs. These classes differ in tissue and subcellular distribution, induction by RA, structure of the 5'-UT region and mRNA stability: these features are compatible with a differential function of the two classes of transcripts in embryogenesis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
Z. Wang, M. Weaver, and N. S. Magnuson
Cryptic promoter activity in the DNA sequence corresponding to the pim-1 5'-UTR
Nucleic Acids Res., April 20, 2005; 33(7): 2248 - 2258.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Otulakowski, T. Freywald, Y. Wen, and H. O'Brodovich
Translational activation and repression by distinct elements within the 5'-UTR of ENaC alpha -subunit mRNA
Am J Physiol Lung Cell Mol Physiol, November 1, 2001; 281(5): L1219 - L1231.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. V. Patel, R. Sharangpani, S. Bandyopadhyay, and P. E. DiCorleto
Endothelial Cells Express a Novel, Tumor Necrosis Factor-alpha -regulated Variant of HOXA9
J. Biol. Chem., January 15, 1999; 274(3): 1415 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Folberg, E. N. Kovacs, and M. S. Featherstone
Characterization and Retinoic Acid Responsiveness of the Murine Hoxd4 Transcription Unit
J. Biol. Chem., November 14, 1997; 272(46): 29151 - 29157.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A Morrison, L Ariza-McNaughton, A Gould, M Featherstone, and R Krumlauf
HOXD4 and regulation of the group 4 paralog genes
Development, January 8, 1997; 124(16): 3135 - 3146.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. E. Haerry and W. J. Gehring
Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can functionas an enhancer element in Drosophila
PNAS, November 26, 1996; 93(24): 13884 - 13889.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A Morrison, M. Moroni, L Ariza-McNaughton, R Krumlauf, and F Mavilio
In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer
Development, January 6, 1996; 122(6): 1895 - 1907.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
M. S. Carter and P. Sarnow
Distinct mRNAs That Encode La Autoantigen Are Differentially Expressed and Contain Internal Ribosome Entry Sites
J. Biol. Chem., September 1, 2000; 275(36): 28301 - 28307.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.