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Nucleic Acids Research, 1990, Vol. 18, No. 18 5375-5380
© 1990

MOLECULAR BIOLOGY

Evidence for a feedback regulated back-up promoter which controls permanent expression of a Dictyostelium gene

Markus Maniak and Wolfgang Nellen*

Max-Planck-Institut für Biochemie, Abt. Zellbiologie, D-8033 Martinsried, FRG

*To whom correspondence should be addressed

Received July 11, 1990. Revised August 15, 1990. Accepted August 15, 1990.

We have previously described the elements of two overlapping promoters regulating differential expression of the DictyosteliumP8A7 gene. One promoter was constitutively active but stimulated during development (S-promoter), while the other (L-promoter) was found to be induced by a variety of stimuli. This effect was mediated by the induction (i-) element. By a series of antisense transformation experiments we here provide evidence that this element is the target of a feedback control circuit. In wild type cells, feedback regulation activates the L-promoter in unfavourable environmental situations when transcription from the S-promoter is insufficient to generate adequate amounts of protein. A model for the function of the feedback loop under natural and experimental conditions is presented.


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