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Nucleic Acids Research, 1990, Vol. 18, No. 18 5489-5494
© 1990

MOLECULAR BIOLOGY

A novel RNA helicase gene tightly linked to the Triplolethal locus of Drosophila

Douglas R. Dorer, Alan C. Christensen* and Daniel H. Johnson1

Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University 1020 Locust Street, Philadelphia, PA 19107, USA 1Department of Biochemistry and Molecular Biology, University of Miami School of Medicine 1550 Northwest 10th Avenue, Miami, FL 33136, USA

*To whom correspondence should be addressed

Received June 5, 1990. Revised August 6, 1990. Accepted August 6, 1990.

The Triplo-lethal (Tpl) locus of Drosophila is the only known locus which is lethal when present in three copies rather than the normal two. After recovering a hybrid-dysgenesis-induced mutation of Tpl we used a rapid combination of transposon tagging, chromosome microdissection and PCR to clone the P element that had transposed into the Tpl region. That P element is located within the gene for a new and unique member of the RNA helicase family. This new helicase differs from all others known by having glycine-rich repeats at both the amino and carboxyl termini. Curiously, genetic analysis shows that the P element inserted into this gene is not responsible for the Tpl mutant phenotype. We present possible explanations for these findings.


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