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Nucleic Acids Research, 1990, Vol. 18, No. 19 5751-5757
© 1990

MOLECULAR BIOLOGY

Genomic organization of the transposable element Tdd-3 from Dictyostelium discoideum

Rolf Marschalek, Gabi Borschet and Theodor Dingermann*

Institut für Biochemie, Medizinische Fakultät, Universität Erlangen-Nümberg Fahrstraße 17, D-8520 Erlangen, FRG

*To whom correspondence should be addressed

Received June 18, 1990. Revised August 17, 1990. Accepted August 17, 1990.

The transposable element Tdd-3 from D. discoideum has been described originally In 1984 (Poole and Firtel, 1984). Additional copies of this element were discovered in the course of a recent study on tRNA gene organization in D. discoideum. Five out of 24 independently isolated tRNA genes proved to be associated with Tdd-3 elements. The surprising observation that all the elements always occurred within the 3'-flanking sequences of the Dictyostelium tRNA genes suggested the possibility of a general position specific integration of Tdd-3 elements upon transposition. Therefore we isolated additional Tdd-3 elements from various genomic D. discoideum libraries in order to test this hypothesis. Several new Tdd-3 elements were found associated with various tRNA genes. Additionally we identified Tdd-3 elements organized In tandem array or In association with RED (Repetitive Element of Dictyostelium), another repetitive element recently identified by our laboratory. In all cases a B-box equivalent of the eukaryotic gene-internal RNA polymerase III promoter was identified upstream of all Tdd-3 elements.


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[Abstract] [Full Text]


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