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Nucleic Acids Research, 1990, Vol. 18, No. 19 5811-5816
© 1990

MOLECULAR BIOLOGY

HrpF, a human sequence-specific DNA-binding protein homologous to XrpFl, a Xenopus Iaevis oocyte transcription factor

Giorgio Lagna+, Fabrizio Loreni1, Elena Beccari and Francesca Carnevali*

Centro di Studio per gil Acidi Nucleici, Dipartimento di Genetica e Biologia Molecolare, Universita' di Roma ‘La Sapienza’ P.le A.Moro 5, 00185 Roma 1Dipartimento di Biologia, Universita' di Roma Tor Vergata, via O.Raimondo 1, 00173 Roma, Italy

* To whom correspondence should be addressed

Received May 2, 1990. Revised September 10, 1990. Accepted September 10, 1990.

The identification in HeLa nuclei of a novel DNA-binding protein, designated HrpF, is presented. This factor recognizes and binds a sequence of the Xenopus Iaevis L14 ribosomal protein (r-p) gene promoter bound by the Xenopus r-p transcription factor I (XrpFl) (1). We show here that XrpFl and HrpF share a conserved DNA-binding domain. We also present evidences suggesting that the two factors perform similar functions in the cell. We discuss the hypothesis that closely related factors might be involved in the control of rp-gene transcription in vertebrates.

+ Present address: Laboratory of Biochemisoy and Molecular Biology, The Rockefeller University, New York, NY, USA


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