Nucleic Acids Research, 1990, Vol. 18, No. 20 6101-6106
© 1990
MOLECULAR BIOLOGY |
Homeobox containing genes in the nematode Caenorhabditis elegans
Department of Medical Biochemistry, University of Calgary Calgary, Alberta T2N 4N1, Canada
*To whom correspondence should be addressed at Biology Department, Princeton University, Princeton, NJ 08544, USA
Received May 25, 1990. Revised August 31, 1990. Accepted August 31, 1990.
We designed a unique 36-mer oligonucleotide probe, based on the most highly conserved amino acid sequences of Antennapedia-like homeodomains and the codon bias of Caenorhabditis elegans. This probe was then used to isolate four classes of genes from a C. elegans genomic library. Sequencing reveals that we have isolated three new homeobox genes, designated ceh-1, ceh-9 and ceh-10. The fourth homeobox gene, ceh-11, has recently been described by Schaller et al (Nucleic Acids Res. 18, 2033–2036). The amino acid sequence of ceh-1 is 87% similar to the honeybee H40 homeodomain, 85% similar to the Drosophila NK-1 homeodomain and 82% similar to the chicken CHox3 homeodomain. The sequence ceh-10 appears to be a member of the paired class of homeodomains. The other two sequences, ceh-9 and ceh-11, remain unclassified. Three of the four sequences have at least one intron within the homeobox region. Transcripts of ceh-10 and ceh-11 are present in embryonic RNA but are greatly diminished in later developmental stages. Three of the four new genes have been placed on the C. elegans genomic map.
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