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Nucleic Acids Research, 1990, Vol. 18, No. 22 6491-6495
© 1990

CHEMISTRY

Solid-phase synthesis of H-Phe-Tyr-(pATAT)-NH2: a nucleopeptide fragment from the nucleoprotein of bacteriophage øX174

C.M. Dreef-Tromp, E.M.A. van Dam, H. van den Elst, G.A. van der Marel and J.H. van Boom*

Gorlaeus Laboratories PO Box 9502, 2300 RA Leiden, The Netherlands

*To whom correspondence should be addressed

Received September 26, 1990. Accepted October 17, 1990.

The preparation of the nucleopeptide H-Phe-Tyr-(pATAT)-NH2 could be realized via a solid phase phosphitetrlester approach and by using the protected protecting group 2-(tert-butyldiphenylsilyloxymethyl)-benzoyl for the masking of the N6-amino function of deoxyadenoslne. The latter protecting group can be removed under mild conditions with fluoride ion.


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