Nucleic Acids Research, 1990, Vol. 18, No. 23 6857-6862
© 1990
Articles |
COUP-TF gene: a structure unique for the steroid/thyroid receptor superfamily
Department of Cell Biology, Baylor College of Medicine Houston, TX 77030, USA
* To whom correspondence should be addressed
Received September 11, 1990. Revised November 2, 1990. Accepted November 2, 1990.
Two different genomic genes for the COUP-transcription factor, COUP-TF I and COUP-TF II, have been isolated from a human cosmid genomic library using a [32P]-labeled cDNA probe. Data obtained from Southern blot analysis of these cosmid clones indicated that two closely related genes exist in the human genome and have a similar genomic organization. The genes are similar in the hormone and DNA binding domains but diverge from one another in the N-terminal region. Using DNA sequencing and polymerase chain reaction (PCR) techniques we have determined that the structure of COUP-TF I consists only of three exons and two Introns. Surprisingly, both zinc fingers (i.e., F1 and F2) are located in the first exon. Therefore, COUP-TF I is unique among the members of the steroid/thyroid hormone receptor superfamily which have been described to date.
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