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Nucleic Acids Research, 1990, Vol. 18, No. 4 779-783
© 1990

MOLECULAR BIOLOGY

Insertion of an LrDNA gene fragment and of filler DNA at a mitochondrial exon-intron junction in Podospora

Annie Sainsard-Chanet and Odile Begel

Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique 91190 Gif sur Yvette, France

Received November 21, 1989. Accepted January 2, 1990.

A rearrangement of the mitochondrial genome of a long lived mutant of Podospora anserina is presented. It consists in the insertion of 191 bp of the LrDNA gene (coding for the large ribosomal RNA) at the junction between exonl and intron {alpha} of gene col (coding for subunit 1 of cytochrome oxidase). This insertion is accompanied by a 53 bp deletion of the junction and the presence of extra A and T nucleotides at both sides of the inserted sequence. We discuss possible mechanisms of production of this rearrangement. The presence of extra nucleotides at the recombination junctions suggests that it may pass through a stage of free DNA ends originating from a DNA break at the junction between exonl and intron a of gene col. The possibility that such a DNA break plays a major role in the instability of the mitochondrial genome is envisaged


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