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Nucleic Acids Research, 1990, Vol. 18, No. 4 865-870
© 1990

MOLECULAR BIOLOGY

Readthrough transcription occurs at the rho dependent signal F1 TIV in suppressor cells

Mario La Farina*, Vincenzo Izzo1, Maria A. Costa, Rainero Barbier, Giovanni Duro1, Maria Vitale and Vincenzo Mutolo

Dipartimento di Biologia Cellulare e dello Sviluppo dell ‘Universita’ via Archirafi 22, 90123 Palerrno 1Istituto di Biologia dello Sviluppo del CNR via Archirafi 20, 90123 Palermo, Italy

*To whom correspondence should be addressed

Received November 9, 1989. Revised February 1, 1990. Accepted February 1, 1990.

Suppressor cells Infected with bacteriophage f1 yield phage encoded gene IV transcripts longer than those present in the sup° host and identical to those found in a rho- host. However, such longer transcripts do not appear in the suppressor-infected cell when, by changing the translation frame of gene IV, the ribosome is not allowed to proceed to the end of the gene IV message and thus to reach the rho dependent transcription terminator f1 TIV This suggests that ribosome movement beyond the natural gene IV stop codon disturbs the activity of that termination signal. in contrast to the rho- behaviour, the suppressor does not accumulate high levels of gene IV messages indicating that the accumulation occurring in the rho mutant may not be a primary effect of the readthrough per Se.


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Rho-dependent terminators and transcription termination.
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