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Nucleic Acids Research, 1990, Vol. 18, No. 5 1099-1102
© 1990

CHEMISTRY

Synthesis and characterization of a ribavirin-3', 5'-phosphate pentadecamer homoribopolymer bearing a 5'-amino tether group and a 3'-thymidine

M.I. Dawson*, A.N. Jina, S. Torkelson, S. Rhee, M. Moore, D.A. Zarling and P.D. Hobbs

Bio-Organic Chemistry Laboratory SRI International, Menlo Park, CA 94025, USA

*To whom correspondence should be addressed

Received January 2, 1990. Revised February 9, 1990. Accepted February 9, 1990.

The synthesis of a pentadecamer of the 5'-phosphate of the antiviral nucleoside ribavirin (1'-ß-D-ribofuranosyl-1H-1, 2, 4-triazole-3-carboxamide) has been achieved. This homoribopolymer is terminated at the 5'-position with an (6-aminohexyl)phosphate group to permit conjugation to a carrier and at the 3'-position by a thymldlne-5'-phosphate. The synthesis was accomplished using the methyl phosphoramldite approach to ollgorlbonucleotides. The homoribopolymer was insensitive to ribonuclease A but was sensitive to ribonuclease T2 digestion.


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