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Nucleic Acids Research, 1990, Vol. 18, No. 6 1625-1628
© 1990

MOLECULAR BIOLOGY

Prediction of oligonucleotide frequencies based upon dinucleotide frequencies obtained from the nearest neighbor analysis

Juan Hong

Biochemical Engineering Program, School of Engineering, University of California Irvine, CA 92717, USA

Received March 24, 1989. Revised December 15, 1989. Accepted December 15, 1989.

A statistical method of predicting hexanucleotide frequencies is presented. The method requires dinucleotide frequencies which can be readily obtained by nearest neighbor analysis. The frequencies of 64 hexanucleotides of E. coli were estimated and compared well with those predicted by a third order Markov chain.


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