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Nucleic Acids Research, 1990, Vol. 18, No. 7 1847-1852
© 1990

MOLECULAR BIOLOGY

Application of a new method of pattern recognition in DNA sequence analysis: a study of E.coli promoters

Nickolai N. Alexandrov and Andrei A. Mironov

Genetics of Microorganisms Institute 1-st Dorozhny pr. 1, Moscow 113545, USSR

Received October 18, 1989. Revised March 12, 1990. Accepted March 12, 1990.

An algorithm from the pattern recognition theory ‘generalized portrait’ was used to find a distinguishing vector (scoring matrix) for E.coli promoters. We have attempted to solve three closely linked problems: (i) the selection of significant features of the signal; (ii) subsequent multiple alignment and (iii) calculation of the vector coordinates. Promoters with known strength have been successfully ranked in the correct order using this vector. We demonstrate the use of this method in predicting the location of promoters. A revised consensus promoter sequence is also presented.


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