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Nucleic Acids Research, 1991, Vol. 19, No. 10 2539-2566
© 1991

SURVEY AND SUMMARY

Organization of restriction-modification systems

Geoffrey G. Wilson

New England Biolabs, Inc. 32 Tozer Road, Beverly, MA 01915, USA

Received February 13, 1991. Revised April 10, 1991. Accepted April 10, 1991.

The genes for over 100 restriction-modification systems have now been cloned, and approximately one-half have been sequenced. Despite their similar function, they are exceedingly heterogeneous. The heterogeneity is evident at three levels; In the gene arrangements; In the enzyme compositions; and in the protein sequences. This paper summarizes the main features of the R-M systems that have been cloned.


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