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Nucleic Acids Research, 1991, Vol. 19, No. 10 2579-2586
© 1991

MOLECULAR BIOLOGY

Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY

M. North, C. Sargent, J. O'Brien, K. Taylor1, J. Wolfe1, N.A. Affara* and M.A. Ferguson-Smith

University of Cambridge Department of Pathology Tennis Court Road, Cambridge CB2 1QP 1Department of Genetics, The Galton Laboratory, University College London London, UK

* To whom correspondence should be addressed

Received March 14, 1991. Revised April 18, 1991. Accepted April 18, 1991.

We have cloned and sequenced transcripts from the X- and Y-linked zinc-finger genes ZFX and ZFY respectively and discuss a possible mechanism of posttranscriptional control by which these genes can be widely expressed but translated in only specific tissues. We report the identification of a novel 3'UTR (untranslated region) present in ZFY which is highly conserved among primates and contains a series of motifs implicated as mRNA instability determinants. These sequences can be substantially removed by polyadenylation directed from consensus (AATAAA) and non-consensus (AATATAAA) sequences In adult testis. The DNA-binding domains of the ZFY and ZFX proteins are compared using present models for zincfinger/DNA interactions. Additionally, the genomic organisation of the ZFY coding sequence is presented as compared to that of ZFX.


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