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Nucleic Acids Research, 1991, Vol. 19, No. 10 2587-2593
© 1991

CHEMISTRY

Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl) adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides

Koen Augustyns, Arthur Van Aerschot, Ann Van Schepdael, Claus Urbanke1 and Piet Herdewijn*,+

Rega Institute for Medical Research Minderbroedersstraat 10, B-3000 Leuven, Belgium 1Medizinische Hochschule Konstanty Gutschow Strasse 8, 3000 Hannover, FRG

* To whom correspondence should be addressed

Received March 7, 1991. Accepted April 19, 1991.

(S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated.

+ Supplementary material concerning UV and NMR data is available on request at the author's address


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