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Nucleic Acids Research, 1991, Vol. 19, No. 11 2869-2874
© 1991

MOLECULAR BIOLOGY

A U6 snRNA gene with an Internal promoter is juxtaposed to an snRNP protein sequence within an intron of a human G protein gene

Eric D. Wieben, Anne M. Vrabel, Eileen L. Holicky, Ivana Klisak1, Robert S. Sparkes1 and David R. Stanford

Department of Biochemistry and Molecular Biology, Mayo Clinic/Foundation Rochester, MN 55905 1Department of Medicine, UCLA Center for the Health Sciences, UCLA Los Angeles, CA 90024, USA

Received March 19, 1991. Revised April 7, 1991. Accepted April 7, 1991.

A complex locus on human chromosome 1 brings together sequences homologous to a G protein and two components of the RNA processing machinery of eukaryotic cells. Specifically, the seventh intron of the human Gi3{alpha} gene contains a fusion of a partial snRNP E protein pseudogene to a variant U6 snRNA gene. The novel U6 sequence contains nine point mutations and a one nucleotide deletion relative to the major U6 gene from humans. Unlike all other vertebrate U6 genes characterized to date, the variant U6 gene is efficiently transcribed by RNA polymerase III even in the absence of all natural flanking sequences. The union of elements from the signal transduction pathway and the RNA processing machinery suggests the possibility of functional interplay.


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A. M. Domitrovich and G. R. Kunkel
Multiple, dispersed human U6 small nuclear RNA genes with varied transcriptional efficiencies
Nucleic Acids Res., May 1, 2003; 31(9): 2344 - 2352.
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