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Nucleic Acids Research, 1991, Vol. 19, No. 11 3081-3088
© 1991

MOLECULAR BIOLOGY

Xenopus laevis c-myc I and II genes: molecular structure and developmental expression

Etienne Principaud and Georges Spohr

Université de Genève, Département de Biologie Cellulaire, Sciences III, 30 Quai Ernest Ansermet 1211 Geneva 4, Switzerland

Received January 14, 1991. Revised May 3, 1991. Accepted May 3, 1991.

The structure of the two Xenopus laevis c-myc I and c-myc II genes has been investigated by isolating and sequencing genomic and cDNAs clones. In oocytes, c-myc I mRNAs represent 80 – 90% of the overall amount of c-myc transcripts. The c-myc I expression is controlled primarily by two differentially regulated tandem promoters P1 and P2 which are separated by 50 bases. During oogenesis, maternal c-myc I mRNAs, are transcribed from both promoters whereas zygotic transcripts seem to initiate only from the P2 promoter. Sequence comparison between the promoter regions of c-myc I and II genes reveals the insertion in the c-myc I promoter region, between positions –831 and –389 relative to the P1 start site of a repetitive element. Comparison of X.laevis and mammalian c-myc promoter sequences reveals furthermore the conservation of cis-regulatory elements, including a motif known to be a negative regulator of the human c-myc transcription, a purine rich region, a binding site for the E2-F transcription factor and three SP1 binding sites. Finally, we report characterization of a new c-myc I mRNA which differ at the 5' end. Transcripts are possibly initiated at a putative alternative promoter located further upstream in the genome, and undergoes alternative splicing.


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