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Nucleic Acids Research, 1991, Vol. 19, No. 12 3269-3274
© 1991

MOLECULAR BIOLOGY

Two hypervarlable minisatellite DNA binding proteins

Wayne p. Wahls*, Greg Swenson1 and Peter D. Moore

Departments of Genetics E-808 S. Wood Street, Chicago, IL 60612, USA 1Departments of Microbiology and Immunolgoy, university of lllinois at Chicago E-808 S. Wood Street, Chicago, IL 60612, USA

*To whom correspondence should be addressed at Fred Hutchinson Cancer Research Center, M621, 1124 Columbia Street, Seattle, WA 98104, USA

Received March 26, 1991. Revised May 18, 1991. Accepted May 18, 1991.

Hypervarlable minisatellite DNA sequences are short, tandemly repeated sequences present at numerous loci in eukaryotes. They stimulate intermolecular homologous recombination up to 13-fold in human cells in culture and may be specific sites for the initiation of recombination in the eukaryotic genome (Wahls, W.P., Wallace, L.J., & Moore, P.D. (1990) Cell 60, 95-103). Reported here is the detection and partial purification of two hypervariable minisatellite DNA binding proteins, called Msbp-2 and Msbp-3, present in the nuclear extracts of human HeLa cells. The proteins elute from a gel filtration column with a native mass of 200 - 250 kDa and have sizes of 77 kDa and 115 kDa respectively.


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