Nucleic Acids Research, 1991, Vol. 19, No. 13 3709-3714
© 1991
MOLECULAR BIOLOGY |
Developmental regulation of transcription factor AP-2 during Xenopus laevis embryogenesis
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health Bethesda, MD 20892, USA
* To whom correspondence should be addressed
Received January 22, 1991. Revised April 22, 1991. Accepted April 22, 1991.
We have isolated a cDNA clone encoding the Xenopus homologue of the transcription factor AP-2 (XAP-2). The predicted amino acid sequence derived from the Xenopus cDNA shows very strong conservation with the amino acid sequence of human AP-2, suggesting that this protein is evolutionarily conserved, at least among vertebrates. This is further substantiated by the demonstration that an in vitro translation product of XAP-2 cDNA bound specifically to an AP-2 binding site from the human MT-IIA gene. Northern blot analysis of Xenopus embryo RNA revealed the existence of three major XAP-2 mRNA species that were only detectable after the midblastula transition (when embryonic transcription is activated), with peak accumulation of the transcripts occurring during gastrulation. Therefore, in contrast to other Xenopus transcription factors, XAP-2 is not maternally derived but arises exclusively from zygotic transcription. Unlike the situation in cultured human teratocarcinoma (NT2) cells, retinoic acid treatment did not induce XAP-2 mRNA in Xenopus embryos, even though the treatment had a pronounced morphogenetic effect on the embryos. Our results suggest that XAP-2 may play a distinctive role during Xenopus embryogenesis.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Shnitsar and A. Borchers PTK7 recruits dsh to regulate neural crest migration Development, December 15, 2008; 135(24): 4015 - 4024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Luo, Y. Xu, T. L. Hoffman, T. Zhang, T. Schilling, and T. D. Sargent Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development Development, April 1, 2007; 134(7): 1279 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Lim, A. B. Booker, T. Luo, T. Williams, Y. Furuta, O. Lagutin, G. Oliver, T. D. Sargent, and J. R. Fallon AP-2{alpha} selectively regulates fragile X mental retardation-1 gene transcription during embryonic development Hum. Mol. Genet., July 15, 2005; 14(14): 2027 - 2034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Park, N. Warner, Y.-S. Bong, D. Stapleton, R. Maeda, T. Pawson, and I. O. Daar Ectopic EphA4 Receptor Induces Posterior Protrusions via FGF Signaling in Xenopus Embryos Mol. Biol. Cell, April 1, 2004; 15(4): 1647 - 1655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Zhou and C.-M. Chiang Sp1 and AP2 regulate but do not constitute TATA-less human TAFII55 core promoter activity Nucleic Acids Res., October 1, 2002; 30(19): 4145 - 4157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Park, N. Warner, K. Mood, T. Pawson, and I. O. Daar Low-Molecular-Weight Protein Tyrosine Phosphatase Is a Positive Component of the Fibroblast Growth Factor Receptor Signaling Pathway Mol. Cell. Biol., May 15, 2002; 22(10): 3404 - 3414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Maeda, A. Ishimura, K. Mood, E. K. Park, A. M. Buchberg, and I. O. Daar Xpbx1b and Xmeis1b play a collaborative role in hindbrain and neural crest gene expression in Xenopus embryos PNAS, April 16, 2002; 99(8): 5448 - 5453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Borchers, R. David, and D. Wedlich Xenopus cadherin-11 restrains cranial neural crest migration and influences neural crest specification Development, August 15, 2001; 128(16): 3049 - 3060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Nyormoi, Z. Wang, D. Doan, M. Ruiz, D. McConkey, and M. Bar-Eli Transcription Factor AP-2{alpha} Is Preferentially Cleaved by Caspase 6 and Degraded by Proteasome during Tumor Necrosis Factor Alpha-Induced Apoptosis in Breast Cancer Cells Mol. Cell. Biol., August 1, 2001; 21(15): 4856 - 4867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Kerber, I Monge, M Mueller, P. Mitchell, and S. Cohen The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development Development, January 4, 2001; 128(8): 1231 - 1238. [Abstract] [PDF]
|
|
|
|
|
|
M Pasqualetti, M Ori, I Nardi, and F. Rijli Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus Development, January 12, 2000; 127(24): 5367 - 5378. [Abstract] [PDF]
|
|
|
|
|
|
H Epperlein, D Meulemans, M Bronner-Fraser, H Steinbeisser, and M. Selleck Analysis of cranial neural crest migratory pathways in axolotl using cell markers and transplantation Development, January 6, 2000; 127(12): 2751 - 2761. [Abstract] [PDF]
|
|
|
|
 |
|
 J. B. Redell and B. L Tempel Multiple Promoter Elements Interact to Control the Transcription of the Potassium Channel Gene, KCNJ2 J. Biol. Chem., August 28, 1998; 273(35): 22807 - 22818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Saint-Jeannet, X. He, H. E. Varmus, and I. B. Dawid Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a PNAS, December 9, 1997; 94(25): 13713 - 13718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Geimonen, W. Jiang, M. Ali, G. I. Fishman, R. E. Garfield, and J. Andersen Activation of Protein Kinase C in Human Uterine Smooth Muscle Induces connexin-43 Gene Transcription through an AP-1 Site in the Promoter Sequence J. Biol. Chem., September 27, 1996; 271(39): 23667 - 23674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Mallow, A. Harris, N. Salzman, J. P. Russell, R. J. DeBerardinis, E. Ruchelli, and C. L. Bevins Human Enteric Defensins J. Biol. Chem., February 23, 1996; 271(8): 4038 - 4045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Moser, A Imhof, A Pscherer, R Bauer, W Amselgruber, F Sinowatz, F Hofstadter, R Schule, and R Buettner Cloning and characterization of a second AP-2 transcription factor: AP-2 beta Development, January 9, 1995; 121(9): 2779 - 2788. [Abstract] [PDF]
|
|
|
|
|
|
C. Byrne, M. Tainsky, and E. Fuchs Programming gene expression in developing epidermis Development, September 1, 1994; 120(9): 2369 - 2383. [Abstract] [PDF]
|
|
|
|
|
|
T. J. Schuh, B. L. Hall, J. C. Kraft, M. L. Privalsky, and D. Kimelman v-erbA and citral reduce the teratogenic effects of all-trans retinoic acid and retinol, respectively, in Xenopus embryogenesis Development, November 1, 1993; 119(3): 785 - 798. [Abstract] [PDF]
|
|
|
|
|
|
S. Wankhade, Y. Yu, J. Weinberg, M. A. Tainsky, and P. Kannan Characterization of the Activation Domains of AP-2 Family Transcription Factors J. Biol. Chem., September 15, 2000; 275(38): 29701 - 29708. [Abstract] [Full Text] [PDF]
|
|