Nucleic Acids Research, 1991, Vol. 19, No. 14 3861-3865
© 1991
GENOME STRUCTURE AND MAPPING |
Striking homology of the ‘Variable’ N-terminal as well as the ‘conserved core’ domains of the mouse and human TATA-factors (TFIID)
1Division of Behavior and Neurobiology, National Institute for Basic Biology Myodaiji-cho, Okazaki 444 2Division of Macromolecular Function, Institute for Protein Research, Osaka University 3-2 Yamada-oka, Suita 565, Japan 3Laboratory of Biochemistry and Molecular Biology, The Rockefeller University New York, NY 10021, USA 4Department of Biochemistry, Faculty of Medicine, The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113, Japan
* To whom correspondence should be addressed at Department of Biochemistry, Saitama Medical School, Moroyama-machi, Saitama 350-04, Japan
Received May 12, 1991. Revised July 1, 1991. Accepted July 1, 1991.
A complementary DNA (cDNA) encoding a mouse TFIID (mlID) was isolated from mouse brain cDNA libraries. The 316 amino acid sequence deduced from cDNA sequences revealed the presence of an amlno-terminal region enriched in serine, threonlne, and prollne (STP-cluster), an uninterrupted stretch of 13 glutamine residues (Q-run), a second STP-cluster, and a conserved carboxy-termlnal region. Amino acid sequences of the first STP-cluster and the conserved carboxy-terminal region were Identical to those of the human TFIID (hllD). However, the Q-run was considerably shorter than that in hllD and sequences in the second STP-cluster diverged from those of the hllD. The murine TFIID transcript Is expressed as a 2 kilobase poly(A)+ RNA In the mouse brain. Southern blot analysis identified a single gene copy per haploid mouse genome.
+ Present address: Biotechnology Research Laboratory, Toshi Co. Ltd, 2743-1 Hayakawa, Ayasa, Kanagawa, Japan
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