Skip Navigation

This Article
Right arrow Print PDF (449K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (62)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Hatta, M.
Right arrow Articles by Takeichi, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hatta, M.
Right arrow Articles by Takeichi, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1991, Vol. 19, No. 16 4437-4441
© 1991

GENOME STRUCTURE AND MAPPING

Genomic organization and chromosomal mapping of the mouse P-cadherin gene

Masayuki Hatta, Seiji Miyatani, Neal G. Copeland1, Debra J. Gilbert1, Nancy A. Jenkins1 and Masatoshi Takeichi*

Department of Biophysics, Faculty of Science, Kyoto University Kitashirakawa, Sakyo-ku, Kyoto 606, Japan 1Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center Frederick, MD 21702, USA

* To whom correspondence should be addressed

Received May 23, 1991. Revised July 18, 1991. Accepted July 18, 1991.

Cadherins are a family of Ca2+ -dependent cell adhesion molecules, that includes P-cadherln, E-cadherin, N-cadherin and L-CAM. In this study, the genomic organization of the mouse P-cadherin gene was determined by analyzing overlapping DNA clones obtained from a mouse genomic library. The results showed that this gene spans over 45kb and consists of 15 exons. A marked feature of this gene is that the first intron is 23kbp long accounting for half its length. Comparisons of this structure with that of L-CAM, a chicken cadherin, revealed that the exon-intron boundaries are conserved between the two genes except that the P-cadherln first exon includes the correspoding first and second exons of the L-CAM gene. This gene was also similar to the other in that the second intron, which corresponds to the P-cadherin first intron, is exceptionally longer than other introns. These results suggest that the exon-intron pattern conserved in these genes is of significance for generation of domain structure of cadherin molecules or for their transcriptional regulation. We also determined the chromosomal localization of the P-cadherin gene by interspecific backcross analysis, and found that this gene is located in the central region of mouse chromosome 8 and linked with the E-cadherin locus. This is the first evidence for the linkage of different cadherin genes.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
C. L. Tinkle, H. A. Pasolli, N. Stokes, and E. Fuchs
New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity
PNAS, October 7, 2008; 105(40): 15405 - 15410.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
W. Harrouk, B. Robaire, and B. F. Hales
Paternal Exposure to Cyclophosphamide Alters Cell-Cell Contacts and Activation of Embryonic Transcription in the Preimplantation Rat Embryo
Biol Reprod, July 1, 2000; 63(1): 74 - 81.
[Abstract] [Full Text]

Home page
 JCBHome page
G. L. Radice, M. C. Ferreira-Cornwell, S. D. Robinson, H. Rayburn, L. A. Chodosh, M. Takeichi, and R. O. Hynes
Precocious Mammary Gland Development in P-Cadherin-deficient Mice
J. Cell Biol., November 17, 1997; 139(4): 1025 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Selig, H. G. W. Lidov, S. A. Bruno, M. M. Segal, and L. M. Kunkel
Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin
PNAS, March 18, 1997; 94(6): 2398 - 2403.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Silos, K. Tamai, K. Li, S. Kivirikko, D. Kouba, A. M. Christiano, and J. Uitto
Cloning of the Gene for Human Pemphigus Vulgaris Antigen (Desmoglein 3), a Desmosomal Cadherin. CHARACTERIZATION OF THE PROMOTER REGION AND IDENTIFICATION OF A KERATINOCYTE-SPECIFIC cis-ELEMENT
J. Biol. Chem., July 19, 1996; 271(29): 17504 - 17511.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S Obata, H Sago, N Mori, J. Rochelle, M. Seldin, M Davidson, T St John, S Taketani, and S. Suzuki
Protocadherin Pcdh2 shows properties similar to, but distinct from, those of classical cadherins
J. Cell Sci., January 12, 1995; 108(12): 3765 - 3773.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
H Matsunami, S Miyatani, T Inoue, N. Copeland, D. Gilbert, N. Jenkins, and M Takeichi
Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene
J. Cell Sci., January 9, 1993; 106(1): 401 - 409.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Wu and T. Maniatis
Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes
PNAS, March 28, 2000; 97(7): 3124 - 3129.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.