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Nucleic Acids Research, 1991, Vol. 19, No. 18 4873-4877
© 1991

MOLECULAR BIOLOGY

The yeast putative transcriptional repressor RGM1 is a proline-rich zinc finger protein

Francisco Estruch

Departament de Bioquímica i Biologia Molecular, Facultats de Ciéncies, Universitat de Valéncia Spain

Received July 1, 1991. Accepted August 23, 1991.

I have cloned a yeast gene, RGM1, which encodes a proline-rich zinc, finger protein. rgm1 mutants do not show any obvious phenotype but overexpression of RGM1 gene greatly impairs cell growth. The prolinerich region of RGM1 attached to a heterologous DNA binding domain is able to repress the expression of the target gene. RGM1 shares similar zinc finger motifs with the mammalian Egr (early growth response) proteins as well as proline-rich sequences with a high serine and threonlne content, suggesting that RGM1 and Egr proteins could have functional similarities.


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