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Nucleic Acids Research, 1991, Vol. 19, No. 18 4879-4883
© 1991

MOLECULAR BIOLOGY

Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO

Kyung-Lib Jang, Bemd Pulverer1, James R. Woodgett1 and David S. Latchman*

Medical Molecular Biology Unit, Department of Biochemistry, University College and Middlesex School of Medicine The Windeyer Building, Cleveland Street, London W1P 6DB 1Ludwig Institute for Cancer Research, University College and Middlesex Hospital Branch 91 Riding House Street, London W1P 8BT, UK

*To whom correspondence should be addressed

Received July 1, 1991. Accepted August 20, 1991.

Lytic infection with herpes simplex virus (HSV) results in the repression of most host cell protein synthesis but produces an increased activity of the cellular AP-1 transcription factor. This increase Is paralleled by an increase In the transcription rate of the proto-oncogene encoding the AP-1 component, c-Jun resulting in an increase in c-Jun protein In infected cells. The increased AP-1 activity in infected cells is dependent upon the HSV immediate-early protein ICPO. Thus a mutant lacking the gene encoding this protein falls to increase AP-1 activity whilst an ICPO expression plasmid can specifically increase the activity of an AP-1 dependent promoter in co-transfection experiments. The Implications of these effects in the interaction of HSV with cultured cells are discussed.


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