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Nucleic Acids Research, 1991, Vol. 19, No. 19 5285-5291
© 1991

MOLECULAR BIOLOGY

An erythroid specific enhancer upstream to the gene encodin the cell-type specific transcription factor GATA-1

Silia Nicolis, Chiara Bertini, Antonella Ronchi, Stefania Crotta, Luisa Lanfranco1, Emanuela Moroni2, Barbara Giglioni2 and Sergio Ottolenghi*

Dipartimento di Genetica e di Biologia dei Microrganismi, Universitá di Milano Milan, Italy 1Dipartimento di Genetica, Biologia e Chimica Medica, Universitá di Trino Milan, Italy 2Centro sullo Studio della Patologia Cellulare del CNR Milan, Italy

*To whom correspondence should be addressed

Received July 4, 1991. Revised September 6, 1991. Accepted September 6, 1991.

The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the celltype specific expression of several genes. We have cloned the mouse and human GATA-1 genes. A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter. The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.


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