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Nucleic Acids Research, 1991, Vol. 19, No. 22 6119-6122
© 1991

MOLECULAR BIOLOGY

Levels of tRNAs in bacterial cells as affected by amino acid usage in proteins

Fumiaki Yamao*, Yoshiki Andachi, Akira Muto, Toshimichi Ikemura1 and Syozo Osawa

Laboratory of Molecular Genetics, Department of Biology, Faculty of Science, Nagoya University Nagoya 464–01 1National Institute of Genetics Mishima 411, Japan

*To whom correspondence should be addressed

Received September 13, 1991. Revised October 28, 1991. Accepted October 28, 1991.

Transfer RNAs of Mycoplasma capricolum were separated by two-dimensional polyacrylamide gel electrophoresis, and the relative abundance of each of the 28 known tRNA species was measured. There existed a correlation between the relative amount of isoacceptor tRNAs and the frequency in choosing synonymous codons that could be translated by the isoacceptors. Furthermore, it was observed that the total amount of tRNAs for a particular amino acid was paralleled by the composition of the amino acid in ribosomal proteins. A similar relationship was obtained from reexamination of the previous data on Escherichia coli tRNAs, suggesting that the amount of tRNAs for an amino acid is affected by the usage of the amino acid in proteins.


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