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Nucleic Acids Research, 1991, Vol. 19, No. 22 6227-6230
© 1991

MOLECULAR BIOLOGY

Expression of adult and tadpole specific globin genes from Xenopus laevis in transgenic mice

Niall Dillon*, George Kollias1, Frank Grosveld1 and Jeffrey G. Williams

Imperial Cancer Research Fund, Clare Hall Laboratories South Mimms, Hertfordshire EN6 3LD 1Laboratory of Gene Structure and Expression, National Institute for Medical Research The Ridgeway, Mill Hill, London NW7 1AA, UK

*To whom correspondence should be addressed at Laboratory of Gene Structure and Expression, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK

Received August 12, 1991. Revised October 15, 1991. Accepted October 15, 1991.

Transgenic mice were generated which carried the adult a and ß-globin genes and the major tadpole specific ß-globin gene of Xenopus laevis. The adult specific a and ß genes were found to express in erythroid tissues in adult mice, while the major tadpole specific (3 gene (ßT1) was expressed in blood from 12.5 day embryos. The pattern of expression of the ßT1 gene during mouse development was consistent with its being regulated as an embryonic globin gene in the mouse. This observation suggests that some of the factors mediating globin switching have been conserved during the evolution of modern amphibia and mammals and raises interesting questions concerning the evolution of vertebrate globin gene switching.


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