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Nucleic Acids Research, 1991, Vol. 19, No. 22 6249-6254
© 1991

MOLECULAR BIOLOGY

Identification of two homologous mitochondrial DNA sequences, which bind strongly and specifically to a mitrochondrial protein of Paracentrotus lividus

Marina Roberti, Anna Mustich, Maria N. Gadaleta and Palmiro Cantatore

Dipartimento di Biochimica e Biologia Molecolare, Universita' di Bari Via Amendola 165/a, 70126 Bari, Italy

Received August 6, 1991. Revised October 16, 1991. Accepted October 16, 1991.

Using a combination of band shift and DNasel protection experiments, two Paracentrotus lividus mitochondrial sequences, able to bind tightly and selectively to a mitochondrial protein from sea urchin embryos, have been found. The two sequences, which compete with each other for binding to the protein, are located in two genome regions which are thought to contain regulatory signals for mitochondrial replication and transcription. A computer analysis suggests that the sequence TTTTRTANNTCYYATCAYA, common to the two binding regions, is the minimal recognition signal for the binding to the protein. We discuss the hypothesis that the protein binding capacity of these two sequences is involved in the control of sea urchin mtDNA replication during developmental stages.


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