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Nucleic Acids Research, 1991, Vol. 19, No. 23 6469-6474
© 1991

MOLECULAR BIOLOGY

Molecular cloning of the gene encoding the bovine brain ribonucelase and its expression in different regions of the brain

M.P. Sasso, A. Carsana1, E. Confalone, C. Cosi1, S. Sorrentino, M. Viola+, M. Palmier1, E. Russo and A. Furia*

Department di Chimica Organica e Biologica, Università di Napoli Via Mezzocannone 16, 80134 Napoli 1Instituto di Chimica Biologica, Università di Verona Strada le Grazie, 37134 Verona, Italy

*To whom correspondence should be addressed

Received August 30, 1991. Accepted November 4, 1991.

In this paper we report the molecular cloning of the gene encoding the bovine brain ribonuclease. The nucleotide sequence determined in this work shows a high degree of identity to the homologous gene encoding the bovine pancreatic ribonuclease. Processing of the primary transcripts of these genes also follows a similar pathway, splicing of the unique intron in the 5' untranslated region occurs at corresponding positions. Expression of the bovine brain ribonuclease gene can be detected both at the transcriptional and translational levels in all the regions of the brain examined.

+On leave of absence from the Istitulo di Chimica Biologica, Facoltà di Medicina e Chirurgia dell'Università di Catania, Italy


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