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Nucleic Acids Research, 1991, Vol. 19, No. 23 6541-6545
© 1991

GENOME STRUCTURE AND MAPPING

Isolation and mapping of EVx1, a human homeobox gene homologus to even-skipped, localized at the 5' end of Hox1 locus on chromosome 7

Antonio Faiella, Maurizio D'Esposito, Marco Rambaldi, Dario Acampora, Silvia Balsfiore, Anna Stornaiuolo, Antonio Mallamaci, Enrica Migliaccio, Massimo Gulisano, Antonio Simeone and Edoardo Boncinelli*

International Institute of Genetics and Biophysica CNR, via Marconi, 10, 80215 Naples, Italy

*To whom correspondence should be addressed

Received August 6, 1991. Revised October 28, 1991. Accepted October 28, 1991.

We isolated and mapped the human homeobox gene EVX1. This gene encodes a protein of 407 amino acid residues containing a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. EVX1 belongs to a small family of vertebrate eve-related homeobox genes including human EVX1 and EVX2 genes, their murine homologs, Evx 1 and Evx 2, and the frog Xhox-3 gene. We previously reported that EVX2 is localized at the 5' end of the HOX4 locus on chromosome 2. We show here that EVX1 is localized at the 5' end of the HOX1 locus on chromosome 7, 48 kb upstream from the most 5' of the eleven HOX1 genes, namely HOX1J. Both EVX genes are transcribed in an opposite orientation as compared to that of adjacent HOX genes. Human HOX1 and HOX4 complex loci appear to be both closely linked to a homeobox gene of the EVX family.


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