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Nucleic Acids Research, 1991, Vol. 19, No. 25 7043-7047
© 1991


Foreword

The ste4+ gene, essential for sexual differentiation of Schizosaccharomyces pombe, encodes a protein with a leucine zipper motif

Norika Okazaki, Koei Okazaki, KOichi Tanaka and Haroto Okayama

Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University 3–1 Yamadaoka Suita, Osaka 565, Japan

ste4 mutants of Schlzosaccharomyces pombe are unable to undergo both mating and melosis. We have cloned the ste4+ gene and its cDNA. The gene encodes a 264 amino acid protein with a typical leucine zipper motif homologous with the jun family. However, unlike the jun family, this protein does not have a typical basic region that precedes the leucine zipper. The transcription of this gene absolutely depends on the ste11+ gene and increases several fold upon nitrogen starvation, a general signal for sexual differentiation. Whereas ste4+ is essential for mating and melosis, its overexpression inhibits these processes.


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