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Nucleic Acids Research, 1991, Vol. 19, No. 25 7215-7218
© 1991

Foreword

Activation of endogenous retroviral transcription in SV40 –transformed mouse cells

Paula M. Timmons1,2, Paul M. Brickell1,+, David S. Latchman1,+ and Peter W.J. Rigby1,2,*

1Cancer Research Campaign, Eukaryotic Molecular Genetics Research Group, Department of Biochemistry, Imperial College of Science and Technology London SW7 2AZ 2laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research The Ridgeway, Mill Hill, London NW7 1AA, UK

*To whom correspondences should be addressed

We have previously isolated a number of cDNA clones that correspond to mRNAs present at higher levels in SV40-transformed cells than in the untransformed parental cells (Scott, M.R.D., Westphal, K.-H. and Rigby, P.W.J. (1983) Cell 34, 557–567). We have now determined the nucleotide sequence of the archetypal Set 2 clone, pAG59, and can thus identify if as corresponding to the env gene of the endogenous, ecofroplc C-type retrovirus of Balb/c mice, Emv–1. We have shown that In the subset of SV40-transformed cells that express the provirus both of the proteins encoded by env, gp70 and p15E, are synthesised and that the former is displayed on the cell surface. We discuss the significance of these observations for the biology of SV40 transformation.

+Present address: The Medical Molecular Biology Unit, Department of Biochemistry, University College and Middlesex School of Medicine, The Windeyer Building, Cleveland Street, London WIP 6DB, UK


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