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Nucleic Acids Research, 1991, Vol. 19, No. 25 7251-7257
© 1991

Foreword

Transcriptional selectivity in early mouse embryos: a qualitative studu

Claire Bonnerot, Muriel Vernet1, Gisele Grimber1, Pascale Briand1 and Jean-Francois Nicolas*

Unite de Biologie Moleculaire du Developpement, Institut Pasteur, Unite Associee 1148 du Centre National de la Recherche Scientifique 25 rue du Dr Roux, 75724 Paris Cedex 15 1Laboratoire de Genetique et Pathologie Experimental, INSERM Institut Cochin de Genetique Moleculaire 22 rue Mechain, 75014 Paris, France

*To whom correspondence should be addressed

The mouse zygotic genome is activated at the 2–cell stage. At this stage, microinjected DMA can be expressed and its transcription, analysed qualitatively with LacZ reporter genes, has the following characteristics (i) Sp1–sensitive promoters are active; (ii) the SV40 early promoter does not require upstream enhancers; (iii) genes driven by the –447, +563 region of murime leukemia virus (M-MuLV) are repressed and; (iv) activation of promoters is possible as shown for the promoter of acetylcholone receptor a-subunit by MyoD. This transactivatioo can occur before the formation of the zygotic genome. The transcriptional selectivity of 2–cell embryos also characterizes oocytes and 4–cell embryos. Therefore the elements involved are present in the oocytes and they persist after fertilization. This transcriptional selectivity has numerous common characteristics with that in EC cells, and may be indicative of a genetic control program specific for multipotential cells.


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