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Nucleic Acids Research, 1991, Vol. 19, No. 3 539-545
© 1991

MOLECULAR BIOLOGY

Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues

Wei-fang Shen, Kristina Detmer, Teresa A. Simonitch-Eason, H.Jeffrey Lawrence and Corey Largman*

Martinez VA Medical Center 150 Muir Rd, Martinez, CA 94553 and Department of Internal Medicine, UC Davis School of Medicine Davis, CA, USA

*To whom correspondence should be addressed al Biochemistry Research, Martinez VA Medical Center, 150 Muir Road, Martinez, CA 94553, USA

Received October 22, 1990. Revised December 31, 1990. Accepted December 31, 1990.

The HOX 2.2 homeobox gene is expressed in human hematopoietic cell lines with erythroid features (W.-F. Shen, et al, Proc. Nat I. Acad. Sci. 86, 8536–8540, 1989). Both human and murine Hox 2.2 genes contain a single 1 kb intron which interrupts the sequence encoding the proposed homeobox protein. Four human erythroleukemla cell lines express the spliced, homeobox-coding transcript as the major form of message, and variable low amounts of unspliced HOX 2.2 mRNAs. Murine embryonic tissues and adult kidney and uterus contain approximately equal amounts of transcripts containing this intron and mRNAs from which the Intron has been excised. The spliced transcript encodes a 224 amino acid homeobox protein, while the unspliced transcript would potentially encode a 140 residue protein containing the same N-terminal sequence but lacking the homeodomaln.


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