Nucleic Acids Research, 1991, Vol. 19, No. 4 775-781
© 1991
MOLECULAR BIOLOGY |
Activation of junB by PKC and PKA signal transduction through a novel cis-acting element
Hubrecht Laboratory, Netherlands Institute for Developmental Biology Uppsalalaan 8, 3584 CT Utrecht, The Netherlands 1Laboratory of Experimental Medicine & Endocrinology, Department of Developmental Biology, Campus Gasthuisberg, University of Leuven B-3000 Leuven, Belgium
* To whom correspondence should be addressed
Received November 21, 1990. Revised January 25, 1991. Accepted January 25, 1991.
The product of the junB gene, a gene homologous to the proto-oncogene c-jun, is a component of transcription factor AP-1. JunB expression is modulated by a wide variety of extracellular stimull, such as serum, growth factors, phorbol esters (TPA) and activators of protein kinase A (PKA). In order to study the molecular basis of this complex regulation, we have cloned the mouse junB gene from a genomic testis library, and characterized the junB promoter. Here we show that the junB promoter is activated by serum, TPA, and activated PKA. Sequences located between - 91 and - 44 are necessary for induction. These sequences contain a CAAT box, a G-C rich region and a previously undescribed inverted repeat (IR). The IR element can mediate induction by TPA and PKA when coupled to a heterologous promoter, and specifically binds a protein of 110 kD.
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