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Nucleic Acids Research, 1991, Vol. 19, No. 4 815-821
© 1991

MOLECULAR BIOLOGY

Xenopus laevis Oct-1 does not bind to certain histone H2B gene promoter octamer motifs for which a novel octamer-binding factor has high affinity

Darrin P. Smith and Robert W. Old*

Department of Biological Sciences, University of Warwick Coventry CV4 7AL, UK

* To whom correspondence should be addressed

Received November 6, 1990. Revised January 28, 1991. Accepted January 28, 1991.

Oct-1 and a second, previously unidentified octamerbinding protein (Oct-R) have been identified in extracts of Xenopus laevis oocytes and embryos. Oct-1 does not bind to the octamer motif associated with certain Xenopus laevis histone H2B gene promoters, whereas Oct-R binds well to this motif, but only in the sequence context of the H2B gene promoter.


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