Nucleic Acids Research, 1991, Vol. 19, No. 4 939-943
© 1991
MOLECULAR BIOLOGY |
Selenium induces changes in the selenocysteine tRNA[Ser]Sec population in mammalian cells
Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health Bethesda, MD 20892 1Department of Radiation and Cellular Oncology, University of Chicago Chicago, IL 60639, USA
* To whom correspondence should be addressed
Received August 16, 1990. Accepted January 22, 1991.
Two isoacceptors of selenocysteine tRNA[Ser]Sec are present in higher vertebrates which are responsible for donating selenocysteine to protein. One such selenocysteine containing protein, giutathione peroxidase, requires selenium for its translation and transcription. Since tRNAE[Ser]Sec is a critical component of the glutathione peroxidase translational machinery, the levels and distributions of its isoacceptors were examined from both human and rat cells grown in chemically defined media with and without selenium. Not only did the level of the selenocystelne tRNA[Ser]Sec population increase approximately 20% in cells grown in the presence of selenium, but the distributions of the two isoacceptors also changed relative to each other.
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