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Nucleic Acids Research, 1991, Vol. 19, No. 5 1001-1006
© 1991

MOLECULAR BIOLOGY

Isolation and nucleotide sequence of the Aspergillus restrictus gene coding for the ribonucleolytic toxin restrictocin and its expression in Aspergillus nidulans: the leader sequence protects producing strains from suicide

Bernard Lamy* and Julian Davies

Unite de genie microbiologique, Institut Pasteur 25 rue du Dr Roux, 75724 Paris cedex 15, France

* To whom correspondence should be addressed

Received January 4, 1991. Accepted January 31, 1991.

We describe the cloning and characterization of the gene coding for the ribotoxin restrictocin, from Aspergillus restrictus (gene res, EMBL accession Number X56176 [GenBank] ). This toxin is a potent inhibitor of protein synthesis in eucaryotes and is of potential interest as a component of immunotoxins. To analyze the mechanism of self-protection in the producing organism, the res gene was cloned Into the vector pFB39 and introduced into Aspergillus nidulans. The secretion of active restrictocin from transformants suggests that the pro-toxin is not an active nuclease but is activated during the process of secretion.


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