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Nucleic Acids Research, 1991, Vol. 19, No. 7 1431-1436
© 1991

MOLECULAR BIOLOGY

The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers

Pierre Chardin*, Geneviève Courtois1, Marie-Geneviève Mattei2 and Sylvie Gisselbrecht1

Institut de Pharmacologie du CNRS, Route des Lucioles 06560 Valbonne, France 1Institut Cochin de Génétique Moléculaire 27 rue du Faubourg Saint-Jacques, 75014 Paris, France 2INSERM U.242, Hopital d'Enfants de La Timone 13385 Marseille Cedex 5, France

* To whom correspondence should be addressed

Received January 16, 1991. Revised March 6, 1991. Accepted March 6, 1991.

We have isolated a human cDNA (kup), encoding a new protein with two distantly spaced zinc fingers of the C2H2 type. This gene is highly conserved in mammals and is expressed mainly in hematopoietic cells and testis. Its expression was not higher in the various transformed cells tested than in the normal corresponding tissues. The kup gene is located in region q23–q24 of the long arm of human chromosome 14. The kup protein is 433 a.a. long, has a M.W. close to 50 kD and binds to DNA. Although the structure of the kup protein is unusual, the isolated fingers resemble closely those of the Krüppel family, suggesting that this protein is also a transcription factor. The precise function and DNA motif recognized by the kup protein remain to be determined.


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