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Nucleic Acids Research, 1975, Vol. 2, No. 10 1745-1750
© 1975

Articles

Reaction of a nucleoside 2,4-dinitrophenyl phosphate with fluoride; A convenient method for the preparation of the nucleoside phosphorfluoridate*

Paul W. Johnson, Richard von Tigerstrom** and Michael Smith***

Department of Biochemistry, Faculty of Medicine. University of British Columbia Vancouver. B.C., Canada

Received July 8, 1975.

Examination of the reaction of 2,4-dinitrofluorobenzene with thymidine-5' phosphate in detail reveals that the initial product is the 2,4-dinitrophenyl ester. This reacts with fluoride to produce thymidine-5' phosphorfluoridate. This second reaction provides the basis for the conversion of preformed thymidine-5' 2,4-dinitrophenyl phosphate to thymidine-5' phosphorofluoridate.

*Research supported by the Medical Research Council of Canada

**Department of Microbiology, University of Alberta, Edmonton, Alberta, Canada

***Medical Research Associate, Medical Research Council of Canada


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