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Nucleic Acids Research, 1975, Vol. 2, No. 11 2177-2182
© 1975

Articles

Synthesis of substituted 5-fluoro-5, 6-dihydropyrimidines

D. Cech, L. Hein, R. Wuttke, M.v. Janta-Lipinski+, A. Otto+ and P. Langen+

Humboldt-University of Berlin, Department of Chemistry 104 Berlin, GDR

Received October 15, 1975.

The reaction of 5-substituted uracils with fluorine in acetic acid and other solvents and the following treatment with different alcohols yielded the corresponding 5-fluoro-5,6-substituted-5,6-dihydropyrimidines. Thymine gave 5-fluoro-5-methyl-6-alkoxy-5,6-dihydropyrimidines. 5-Halogeno uracils and 5-nitro uracil were converted into 5-fluoro-5-halogeno-6-hydrozy-5,6-dihydropyrimidines and the 5-nitroanalogue, respectively.

The structures of the compounds were confirmed by mass spectrometry.

+ Academy of Sciences of GDH, Central Institute of Molecular Biology, 1115 Berlin-Buch, GDR


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