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Nucleic Acids Research, 1975, Vol. 2, No. 12 2257-2268
© 1975

Articles

Effect of RNA synthesis on the binding of 3H-cortisol to nuclear ribonucleoprotein particles from rat liver carrying DNA-like RNA in vivo

B. Rüstow, A. Weihe and R. Lindigkeit

Akademie der Wissenschaften der DDR, Zentralinstitut für Molekularbiologie 1115 Berlin-Buch, Lindenberger Weg 70, GDR

3H-cortisol was found to associate with rat liyer nuclear 30S ribonuoleoprotein partioles carrying D-RNA in vivo. No interaction was detectable when RNA synthesis was inhibited by {alpha}-amanitine. The association appears to be specifically for RNP carrying RNA synthesized after the administration of cortisol to adrenaleotomized rats. The DNA/protein/RNA ratioof rat liver nuclei was not effected by {alpha}-amanitine under our conditions. However, the drug caused a 5–10 fold decrease in nuclear uptake of cortisol. The results are discussed in relation to a supposed transfer of cortisol-reoeptor complexes from the chromatin template to the nascent RNA chains.


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