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Nucleic Acids Research, 1975, Vol. 2, No. 2 257-264
© 1975


Articles

Synthesis of pppGpN typs dinucleotide derivatives: the 5' end sequence of some RNAs

A. Simoncsits, J. Tomasz* and J.E. Allende+

Institute of Biophysics, Biological Research Center Hungarian Academy of Sciences, H-6701 Szeged, Hungary +Department of Biology, University of California San Diego, La Jolla, California 92037, USA

To whom all inquiries should be addressed

Received January 2, 1975. A rapid and simple synthesis of pppGpN type /N=C, U or A/ diribonucleotide derivatives is described by coupling guanosine 2',3'-cyclic phosphate 5'-triphosphate with the appropriate ribonucleoside in the presence of ribonuclease T1.


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